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LIF has the capacity to induce terminal differentiation in leukemic cells Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells the induction of neuronal cell differentiation and the stimulation of acute-phase protein synthesis in hepatocytes (By similarity)
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Innovative Grade US Origin Bovine Serum 100ml - Innovative Grade US Origin Bovine Serum from Innovative Research is manufactured using whole blood collections from cows in USDA-approved facilities. The animals used for this material are of US Origin, ensuring that only the highest-quality material is used for the production of the serum.
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A consistent and robust source of pooled donor human hepatocytes is important for DMPK studies With our new proprietary algorithm we are able to predict yield viability and functional phenotype representing the average human populations The DonorPlex Pooled Donor Human Hepatocytes 20 Donor Female is a single gender 20-donor pool designed to function like the average female liver Each batch is characterized for viable yield and CYP1A2 CYP2A6 CYP2B6 CYP2C9 CYP2C19 CYP2E1 CYP3A4 UGT SULT OAT1B1/3 OCT and NTCP activities With our large inventory of single donor human hepatocyte lots and using our proprietary algorithm to predict phenotype we can also custom produce a pooled donor hepatocyte batch with the phenotype to fit your needs DonorPlex Pooled Donor Human Hepatocytes 20 Donor Female hepatocytes are ideally suited for short-term ( 4hrs) in vitro drug clearance assays in a single gender pool
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TGF- 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF- 1 superfamily that share a characteristic cystine knot structure TGF- 1 -2 and -3 are highly pleiotropic cytokines that act as cellular switches to regulate processes such as immune function proliferation and epithelial-mesenchymal transition Each TGF- isoform has some non-redundant function for TGF- 1 mice with targeted deletion show defects in hematopoiesis and endothelial differentiation and died of overwhelming inflammation TGF- 1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF- RII This receptor then phosphorylates and activates a second ser/thr kinase receptor TGF- RI (also called activin receptor like kinase (ALK)-5) or alternatively ALK-1 This complex phosphorylates and activates Smad proteins that regulate transcription
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Innovative Grade US Origin Guinea Pig Complement Serum 10ml - Innovative Grade US Origin Guinea Pig Complement Serum from Innovative Research is manufactured using whole blood collections from guinea pigs. The animals used for this material are of US Origin, ensuring that only the highest-quality material is used for the production of the serum. This product is processed using a proprietary process that preserves complement activity. We do not recommend thawing this product for aliquoting, as this can impact the complement activity
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
TGF- 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF- 1 superfamily that share a characteristic cystine knot structure TGF- 1 -2 and -3 are highly pleiotropic cytokines that act as cellular switches to regulate processes such as immune function proliferation and epithelial-mesenchymal transition Each TGF- isoform has some non-redundant function for TGF- 1 mice with targeted deletion show defects in hematopoiesis and endothelial differentiation and died of overwhelming inflammation TGF- 1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF- RII This receptor then phosphorylates and activates a second ser/thr kinase receptor TGF- RI (also called activin receptor like kinase (ALK)-5) or alternatively ALK-1 This complex phosphorylates and activates Smad proteins that regulate transcription
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Cryopreserved single donor human hepatocytes are characterized for high viability and general Phase I and Phase II metabolism activity in short term suspension metabolism assays The suspension qualified hepatocytes are ideally suited from short-term ( 4 hrs) in vitro drug clearance assays The suspension qualified hepatocytes are not suitable for applications that require hepatocytes cultured in adhered monolayers
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More